|
rs680244
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
|
22899653 |
2012 |
|
rs667282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we did not observe a significant association of each genotype of the two SNPs with risk of gastric cancer (TT/CT vs. CC: adjusted OR = 1.12,95 % CI = 0.86-1.45; p = 0.401 for rs667282 and GG/TG vs. TT: adjusted OR = 1.13,95 % CI = 0.90-1.43; p = 0.300 for rs3743073).The results of our study indicated that these two SNPs at the 15q25 locus did not modify gastric cancer risk and the reported risk SNP at 15q25 may be specific to lung cancer.
|
23576140 |
2013 |
|
rs6495306
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
|
22899653 |
2012 |
|
rs588765
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, rs588765-rs16969968 may be a genetic marker to lung cancer risk, even among never-smokers.
|
26282330 |
2015 |
|
rs503464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, the heterozygous genotype c.-166T>A at rs503464 of CHRNA5 may be associated with reduced risk of lung cancer, thus representing a susceptibility allele in Chinese individuals.
|
23314339 |
2013 |
|
rs481134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The second variant on 15q24-25.1, marked by rs481134, explains an additional 13.2% of population attributable risk for lung cancer.
|
20395203 |
2010 |
|
rs3829787
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two of the polymorphisms (rs3829787 and rs3841324) statistically influenced the risk of developing lung cancer.
|
23011884 |
2013 |
|
rs17486278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CHRNA5 rs17486278 G had OR = 1.28, 95% CI 1.07-1.54 and P = 0.008, whereas CHRNB4 rs7178270 G had OR = 0.78, 95% CI 0.66-0.94 and P = 0.008 for lung cancer risk.
|
20587604 |
2010 |
|
rs17408276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We used urinary biomarkers to test whether two linked lung cancer risk variants in CHRNA3 (rs1051730) and CHRNA5 (rs16969968) are associated with intensity of smoking and exposure to a tobacco-specific carcinogenic nitrosamine per cigarette dose.
|
19010884 |
2008 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The potential association of three polymorphisms in the CHRNA3 (rs1051730(G > A)), CHRNA5 (rs16969968(G > A)), and AGPHD1 (rs8034191(A > G)) with the lung cancer risk has been widely investigated, but the results are inconsistent.
|
27072204 |
2016 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Given the existing evidence that this CHRNA5 variant predicts favorable response to cessation pharmacotherapy, these findings underscore the potential clinical and public health importance of rs16969968 in CHRNA5 in relation to smoking cessation success and lung cancer risk.
|
25873736 |
2015 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Diplotype analysis of rs3841324 with either rs16969968 or rs8034191 showed that these polymorphisms influenced the lung cancer risk independently.
|
22028403 |
2011 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association with lung cancer risk was found for CHRNA5 rs16969968.
|
23178447 |
2013 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two variants in the nicotinic acetylcholine receptor subunit genes CHRNA5 and CHRNA3 on 15q25, rs16969968 and rs578776, were associated with cotinine (P = 0.001 and 0.03, respectively) in current smokers and with lung cancer risk (P < 0.001 and P = 0.001, respectively).
|
21862624 |
2011 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that there are at least two distinct mechanisms conferring risk for nicotine dependence and lung cancer: altered receptor function caused by a D398N amino acid variant in CHRNA5 (rs16969968) and variability in CHRNA5 mRNA expression.
|
19443489 |
2009 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, rs7452888 (6q27) was identified as a possible candidate SNP to influence lung cancer survival, while stratified analysis hinted at a possible role for rs8034191, rs16969968 (15q25.1) and rs4324798 (6p22.1) in influencing survival time in lun</span>g cancer patients who were never-smokers, based on a small sample.
|
21750227 |
2011 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results: 1) underscore the potential value of smoking cessation for all smokers, 2) suggest that CHRNA5 rs16969968 genotype affects lung cancer diagnosis through its effects on smoking, and 3) have potential value for framing preventive interventions for those who smoke.
|
27543155 |
2016 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, to identify genetic factors that modify lung cancer risk, CHRNA5 non-synonymous variant amino acid position 398 (D398N) was identified.
|
19577767 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between 15q25 and the risk of lung cancer were replicated in white ever-smokers (rs16969968: odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.21 to 1.32, P(trend) = 2 x 10(-26)), and this association was stronger for those diagnosed at younger ages.
|
20548021 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further, these results suggest that the association between rs16969968 and lung cancer may be mediated by the quantity of smoke inhaled.
|
23358500 |
2014 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In models adjusting for cigarettes-per-day, we confirm the association between rs16969968 and lung cancer (p<10(-20)) and observe a nominally significant association with COPD (p = 0.01); the other loci are not significantly associated with either lung cancer or COPD after adjusting for rs16969968.
|
20700436 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The increase in cotinine levels indicated an increased risk of lung cancer with each additional copy of the rs1051730-rs16969968 risk allele (per-allele odds ratio = 1.31, 95% CI = 1.21 to 1.42).
|
22534784 |
2012 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
|
29993116 |
2018 |